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KMID : 0861019990140020081
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Korea Journal of Herbology
1999 Volume.14 No. 2 p.81 ~ p.88
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Effect of Rhizoma Acori Graminei Extract on Blood Pressure and Regional Cerebral Blood Flow in Rats
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鄭鉉雨/Jeong, Hyun-Woo
康城溶/白承化/Kang, Sung-Yong/Bak, Seung-Wha
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Abstract
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Rhizoma Acori Graminei(RAG) has been used in Korea for many centuries as a therapeutic agent for cerebral disease. The effect of RAG on the vascular system is not known. The purpose of this study was to determine the effect of RAG on Blood Pressure(BP) and regional Cerebral Blood Flow(rCBF) of male Sprague-Dawely rats. The changes in rCBF were determinated by Laser-Doppler Flowmetry(LDF).
The results were as follows :
1. Blood pressure was not affected by RAG in rats.
2. rCBF was increased by RAG in a dose-dependent manner.
3. Pretreatment with propranolol significantly inhibited RAG induced increased rCBF.
4. Pretreatment with methylen blue and ODQ significantly inhibited RAG induced increased rCBF.
5. Pretreatment with L-NNA significantly inhibited RAG induced increased rCBF.
These results suggest that RAG causes a diverse response of blood pressure and regional cerebral blood flow(rCBF).
The increased in rCBF is also mediated by adrenergic β-receptor, nitric oxide synthease and guanylate cyclase.
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